Mini-Puberty, Physiological and Disordered: Consequences, and Potential for Therapeutic Replacement

January 2026
CHH

What is this article about?

This article examines "mini-puberty"—a period shortly after birth when babies experience a surge in reproductive hormones similar to what happens during puberty. In boys, this occurs during the first 6 months of life and is crucial for normal development of the testes and penis. In conditions like Kallmann syndrome (KS) and congenital hypogonadotropic hypogonadism (CHH), mini-puberty may not occur properly, leading to problems like undescended testes and small penis size.

Why is it important?

Mini-puberty is a critical window for testicular development. During this time, specialized cells in the testes multiply. When there are mor of these cells, there better future fertility potential. Boys who do not have mini-puberty often have lower fertility as adults. Understanding mini-puberty helps doctors diagnose patients earlier and may help guide fertility treatment.

What does this mean for patients?

Early diagnosis during mini-puberty allows for timely treatment that can help testes descend naturally, increase penis size, and improve future fertility potential. Starting treatment early (rather than waiting until teenage years or adulthood) may help improve long-term reproductive outcomes.

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